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Methamphetamine-Using HIV-Positive Men
COCAINE ACCELERATES HIV, SCIENTISTS FIND
Cocaine speeds the spread of HIV in mice and probably does the
same in humans, according to UCLA researchers. Dr. Gayle Baldwin
and her colleagues injected cocaine or a placebo into mice with an
HIV infection. They reported Thursday in the Journal of Infectious
Diseases that the mice who received cocaine had 200 times as many
viral particles in their blood as those that received a placebo.
After 10 days, they also had twice as many HIV-infected cells. The
mice receiving cocaine also had fewer disease-fighting CD4 cells.
METHAMPHETAMINES BOOST VIRUS POWER
Early animal studies indicate cells infected with the feline version
of the AIDS virus boost their power to replicate the deadly microbe
by as much as 15-fold when exposed to methamphetamines.
If confirmed, the
findings might help answer questions about how such viruses as HIV
gain a foothold in the brain. Such insight is important in efforts
to slow or lessen the dementia associated with AIDS and similar
diseases, Ohio State University researchers said in the Journal of
NeuroVirology. "We found that after about two weeks of chronic
methamphetamine exposure, the ability of these infected cell lines
to mass-produce virus increases dramatically," said Michael Podell,
a professor of veterinary clinical sciences and neurosciences. The
concentration of the drug to which the cells were exposed was equal
to an average level of methamphetamine in an adult abuser's
bloodstream, Podell said. Infections with so-called lentiviruses
such as HIV are particularly problematic because these microbes can
escape detection by a healthy immune system, mutate rapidly and lead
to lifelong infection, Podell said.
