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HHMI Bulletin
SAGE KE Science NOW (Science Magazine's Daily News Service)
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Random
Acts Why senescence hits some cells earlier than
others (Telomeres; Senescence). One for All Worm and fly longevity pathway controls
mouse aging, too.
Lean,
Yes--But Mean? Growth hormone thins and strengthens
the elderly, but at a cost (Growth hormone; Clinical trial).
Having It All After All p53 surplus staves off
cancer but doesn't speed aging. Aging
Takes Its Toll Old immune systems lose first line
of defense against invaders (Immunity; Toll-like receptors).
The Plot Thickens on Thin Bones New discoveries
offer promise for the development of bone-building osteoporosis
drugs. Winding
Up to Wind Down Dearth of DNA-loosening enzyme
makes cells slumber (Senescence; Chromatin; Silencing). Tissue-Tampering
Turn-On Protein activates senescence genes (Senescence;
Extracellular matrix). Deadly
Giveaway Protein linked to Parkinson's disease
squanders clearance molecules (Neurodegenerative disease; Parkinson's
disease). Is
Less Enough? Half-dose of antioxidant fosters cancer
but doesn't hasten death (Oxidative stress). Losing
Their Grip Old immune cells let transgressors slip
away (Immunology). Tumor-Free,
But Not in the Clear Off-kilter tumor suppressor
promotes aging and stunts growth (Insulin-related signaling;
Body size). Turning
a Daf Ear to Stress Worm longevity mutation helps
mice fight damage but causes insulin resistance (Genetics; Diabetes).
For
Wnt of Bone Signaling pathway stems age-related
bone loss (Osteoporosis). RAINing
on the RANK Parade Newly identified protein blocks
bone destruction (Osteoporosis; Signal transduction). A
Fix on AlkB DNA-repair protein removes methyl groups
through unprecedented mechanism (DNA repair). NO-aspirin,
No Atherosclerosis Souped-up painkiller fights
blood vessel plaques (Atherosclerosis; Oxidative stress). A
Greasy Way to Die Overabundance of lipids might
doom motor neurons (Amyotrophic lateral sclerosis). Where's
Telomerase? Chromosome-sealing enzyme crisscrosses
the nucleus (Telomeres). Giving
Stroke Its Kick Nitric oxide spurs tissue enzyme
to damage neurons (Neurodegeneration; Stroke). SHIPping
Out Bone Breakers Protein restrains osteoclasts
(Osteoporosis; Bone). Up
All Night Aging disconnects body's timepieces (Circadian
rhythms). Lone
Star Longevity University of Texas aging center
rides into town (Research institutes). The
Nerve of Youth Roving protein might invigorate
developing neurons (Neuroregeneration). New
Life for Old Theory Old mothers produce short-lived
young (Evolution). "Gero-Tech" Sprouts, But Will It Bloom? Researchers
plant seeds, hoping to bring their academic work to market. Eyes
on Epo Will the anemia drug protect vision, too?
(Vision; Apoptosis). Marked
for Death? Scientists expose proteins damaged in
Alzheimer's disease (Alzheimer's disease; Oxidative damage).
Youthful
Restraint Slowed metabolism early in life helps
worms cheat death (Metabolism; Genetics). Tangled
Up in Spools: Surprise change to chromosome protein silences
genes (Chromatin; Silencing) Timing
Is Everything: Enzyme inhibitor first encourages, then blocks
cells from becoming muscle (Muscle; Chromatin)
Procreation
Penalty? Scientists challenge prevailing theory of reproduction
and longevity (Reproduction; Evolution) Tau
Tangler: Protein promotes dementia-associated conglomerations
in flies (Neurodegenerative disease) Spoiled
Stores: Contamination of aged rodent supply impedes research
(Experimental resources) Breaking
Up the T Party: Short-circuited hormone signal keeps old rats
from making testosterone (Sex hormones) The
Big Picture: New and improved microarray experiment reveals aging-related
genomic changes (Genomics) Death
Comes for the Fungus: Yeast protein mimics mammalian cell suicide
trigger (Apoptosis) Attacking
Brawn and Brains: Muscle and brain cells succumb to the same
protein clumps (Alzheimer's disease; Muscle) Playful
Rejuvenation: Researchers turn to music and other diversions
for inspiration (People) Picture
This: NMR provides a glimpse of amyloid fibrils (Amyloid; Structural
biology) Go
Forth and Multiply: Mutations in mitochondrial DNA take over
(Mitochondria) Old
School: Distant relatives share gene-regulating mechanism (Evolution;
Chromatin structure) An Untwister's New Twist Disease-causing helicase
displays unanticipated talents. A
Jump-Start for Replication: When DNA-copying machinery conks
out, Bloom syndrome helicase brings repair proteins to the rescue
(DNA damage) A
Game of Cellular Clue: SOD1, with oxidative damage, in the--mitochondria?
(Oxidative damage; Amyotrophic lateral sclerosis)
Trash
Cache: Secret mitochondrial weapon fights oxidative damage (Oxidative
damage) Twisted
Logic: Discoveries tangle Werner syndrome helicase story (Werner
syndrome) Lucky
or Good? Stem cells' all-around talent disputed (Stem cells)
More Than a Hot Flash Sex hormones control a
wide range of physiological processes, and replacement therapy
might confer similarly broad benefits. Staying
Cool When Dry: Worms surmount desertlike assault (Stress resistance)
Auxiliary
Rustproofing: Pumping up damage fighter lengthens fly life-span
(Oxidative damage) No
Take Backs: Mice that can't get rid of insulin develop signs
of diabetes (Insulin resistance; Diabetes) Big
Mac and Flies: Signaling pathway tells insects when food's on
the table (Insulin-related signaling) And
the Loser Is ...: Silver Fleece Awards "honor" antiaging
quackery (Questionable therapies) Flipping
Out: Crystal structure reveals how nuclear receptors turn on
and off (Hormones; Nuclear receptors) Passing
the BRCA1 Baton: Possible target of anticancer protein identified
(DNA damage; Cancer) Plaques
With a Purpose: Useful fibers in bacteria resemble deadly protein
clumps (Alzheimer's disease) Inside
Job: Alzheimer's protein kills neurons from within (Alzheimer's
disease) Trash
Talk: AGEs might participate in cell-death signal (Cell death;
AGEs) Deadly
Fate: Klotho variant might shorten life-span in humans
as well as rodents (Premature aging) Make
It Snappy: Fibulin-5 helps mice stay supple (Connective tissue)
How a clk Ticks Gene slated to act at
chromosome ends might play more clear-cut role in DNA repair.
Stressed
Out: Activation of damage-fighting molecules wanes in old cells
(Oxidative stress) |
Be Ready