SAGE KE 2003

Fear Factor Timid mice die sooner than more adventurous siblings (Behavior; Hormones).
17 December 2003
R. John Davenport
Sci. Aging Knowl. Environ. 2003 (50), nw171. [DOI: 10.1126/sageke.2003.50.nw171]
[Abstract] [Full text]

Power to the People Move over, worms, flies, and mice. Humans have glitches in insulin-related signaling pathways too.
17 December 2003
R. John Davenport
Sci. Aging Knowl. Environ. 2003 (50), ns8. [DOI: 10.1126/sageke.2003.50.ns8]
[Abstract] [Full text] [PDF]

What's That Smell? Aging flies lose middle-term memory (Memory; Genetics).
10 December 2003
R. John Davenport
Sci. Aging Knowl. Environ. 2003 (49), nw168. [DOI: 10.1126/sageke.2003.49.nw168]
[Abstract] [Full text]

Just a Little Bit A pinch of growth hormone gives young rats an old collection of drug-processing enzymes (Growth hormone; Therapeutics).
3 December 2003
R. John Davenport
Sci. Aging Knowl. Environ. 2003 (48), nw163. [DOI: 10.1126/sageke.2003.48.nw163]
[Abstract] [Full text]

Eat Less, Nurture Neurons Cutting calories curbs production of brain-disabling protein as well as Alzheimer's plaques (Neurodegeneration).
26 November 2003
R. John Davenport
Sci. Aging Knowl. Environ. 2003 (47), nw161. [DOI: 10.1126/sageke.2003.47.nw161]
[Abstract] [Full text]

Whodunit? Product of neuron-damaging enzyme cleared of wrongdoing (Amyotrophic lateral sclerosis; Stroke).
19 November 2003
R. John Davenport
Sci. Aging Knowl. Environ. 2003 (46), nw159. [DOI: 10.1126/sageke.2003.46.nw159]
[Abstract] [Full text]

Consequence, Not Cause Oxidants arise from, but aren't required for, lethal neuron overstimulation (Neurodegeneration; Oxidative damage).
19 November 2003
R. John Davenport
Sci. Aging Knowl. Environ. 2003 (46), nw158. [DOI: 10.1126/sageke.2003.46.nw158]
[Abstract] [Full text]

Brain Lubricant Antiatherosclerosis protein helps brain cells shuttle cholesterol carrier (Alzheimer's disease; Cholesterol).
12 November 2003
R. John Davenport
Sci. Aging Knowl. Environ. 2003 (45), nw153. [DOI: 10.1126/sageke.2003.45.nw153]
[Abstract] [Full text]

Crypt-ic Message Stem cells in the gut pile up mutations in mitochondrial DNA (Mitochondria; Stem cells).
5 November 2003
R. John Davenport
Sci. Aging Knowl. Environ. 2003 (44), nw150. [DOI: 10.1126/sageke.2003.44.nw150]
[Abstract] [Full text]

Bone Surprise Hormone reveals unexpected skeleton-bolstering power (Hormones; Osteoporosis).
22 October 2003
R. John Davenport
Sci. SAGE KE 2003 (42), nw143. [DOI: 10.1126/sageke.2003.42.nw143]
[Abstract] [Full text]

Phosphate Fast Denying a chemical change to a fat-cell protein keeps metabolism healthy (Diabetes; Insulin resistance).
15 October 2003
R. John Davenport
Sci. SAGE KE 2003 (41), nw141. [DOI: 10.1126/sageke.2003.41.nw141]
[Full text]

Taking a Tumble Lung protein flips to stimulate, rather than block, inflammation (Immunology; Signal transduction).
8 October 2003
R. John Davenport
Sci. SAGE KE 2003 (40), nw138. [DOI: 10.1126/sageke.2003.40.nw138]
[Full text]

Messmaker Enzyme creates garbage backup that's linked to Alzheimer's disease (Neurodegeneration; Protein degradation).
1 October 2003
R. John Davenport
Sci. SAGE KE 2003 (39), nw134. [DOI: 10.1126/sageke.2003.39.nw134]
[Full text]

Trouble Starts Within Mitochondria's poisons destabilize the nuclear genome (Mitochondria; Oxidative damage).
24 September 2003
R. John Davenport
Sci. SAGE KE 2003 (38), nw132. [DOI: 10.1126/sageke.2003.38.nw132]
[Full text]

Starve a Neuron, Feed Pneumonia Mice reveal immune changes that might render stroke patients susceptible to infection (Stroke; Immunology).
10 September 2003
R. John Davenport
Sci. SAGE KE 2003 (36), nw124. [DOI: 10.1126/sageke.2003.36.nw124]
[Full text]

Small Groups, Big Trouble Soluble amyloid clumps that disrupt neuron connections amass in Alzheimer's brains (Neurodegeneration).
27 August 2003
R. John Davenport
Sci. SAGE KE 2003 (34), nw119. [DOI: 10.1126/sageke.2003.34.nw119]
[Full text]

Trading Places Mitochondrial exchange makes dumb mice smarter and smart mice dumber (Mitochondria; Cognition).
20 August 2003
R. John Davenport
Sci. SAGE KE 2003 (33), nw117. [DOI: 10.1126/sageke.2003.33.nw117]
[Full text]

Suffocating Aging New model proposes that age-retarding mutations make worms go anaerobic (Genetics; Metabolism).
13 August 2003
R. John Davenport
Sci. SAGE KE 2003 (32), nw112. [DOI: 10.1126/sageke.2003.32.nw112]
[Full text]

Plugging the Memory Drain Blocking transport protein improves learning in old mice (Cognitive changes).
30 July 2003
R. John Davenport
Sci. SAGE KE 2003 (30), nw107. [DOI: 10.1126/sageke.2003.30.nw107]
[Full text]

Invest in the Future, Invest in Yourself Model adds nurturing factor to evolutionary theory of aging (Evolution; Demography; Reproduction).
23 July 2003
R. John Davenport
Sci. SAGE KE 2003 (29), nw102. [DOI: 10.1126/sageke.2003.29.nw102]
[Full text]

Cancer or Aging, Take Your Pick Protein that keeps aging on pace might help oncogene do its dirty work (Cancer; Premature aging).
9 July 2003
R. John Davenport
Sci. SAGE KE 2003 (27), nw97. [DOI: 10.1126/sageke.2003.27.nw97]
[Full text]

Ouch! Glycine puts extra hurt into pain neurons (Pain; Inflammation).
2 July 2003
R. John Davenport
Sci. SAGE KE 2003 (26), nw93. [DOI: 10.1126/sageke.2003.26.nw93]
[Full text] [Diagram]

Trashing a Longevity-Slasher p53 partner disposes of a protein that promotes aging (Cancer; Insulin-related signaling).
2 July 2003
R. John Davenport
Sci. SAGE KE 2003 (26), nw92. [DOI: 10.1126/sageke.2003.26.nw92]
[Full text]

Coming Into Focus New lens-regeneration secrets might improve cataract treatment (Vision; Tissue regeneration).
11 June 2003
R. John Davenport
Sci. SAGE KE 2003 (23), nw85. [DOI: 10.1126/sageke.2003.23.nw85]
[Full text]

Immunity Challenge The immune system falters with age, and researchers are beginning to understand why.
11 June 2003
R. John Davenport
Sci. SAGE KE 2003 (23), oa1. [DOI: 10.1126/sageke.2003.23.oa1]
[Abstract] [Full text] [PDF]

Lost Without a LIM Protein drives cells to wounds (Tissue regeneration; Wound healing).
11 June 2003
R. John Davenport
Sci. SAGE KE 2003 (23), nw82. [DOI: 10.1126/sageke.2003.23.nw82]
[Full text]

Durable Dwarves Stress-resistant cells come in small packages (Stress resistance; Oxidative damage).
4 June 2003
R. John Davenport
Sci. SAGE KE 2003 (22), nw79. [DOI: 10.1126/sageke.2003.22.nw79]
[Full text]

Old Livers Get a Complex Newly discovered protein mélange might prevent old livers from regrowing (Cell cycle; Tissue regeneration).
21 May 2003
R. John Davenport
Sci. SAGE KE 2003 (20), nw73. [DOI: 10.1126/sageke.2003.20.nw73]
[Full text]

Reduced Renewal Meager stem cell cache thins bones in mutant mice (Osteoporosis; Stem cells).
14 May 2003
R. John Davenport
Sci. SAGE KE 2003 (19), nw68. [DOI: 10.1126/sageke.2003.19.nw68]
[Full text]

Go or No-Go? Mixed results complicate hopes for nerve regeneration (Regenerative medicine; Neurodegeneration).
30 April 2003
R. John Davenport
Sci. SAGE KE 2003 (17), nw63. [DOI: 10.1126/sageke.2003.17.nw63]
[Full text]

Mitochondrial Mayhem Alzheimer's protein disarms the cell's energy plant (Mitochondria; Alzheimer's disease).
23 April 2003
R. John Davenport
Sci. SAGE KE 2003 (16), nw60. [DOI: 10.1126/sageke.2003.16.nw60]
[Full text]

Lamin-tation Newly discovered mutation underlies rare premature aging disease (Premature aging; Genetics).
23 April 2003
R. John Davenport
Sci. SAGE KE 2003 (16), nw59. [DOI: 10.1126/sageke.2003.16.nw59]
[Full text]

Foundations of Longevity Genome search turns up targets of life-extending worm protein (Insulin-like signaling).
16 April 2003
R. John Davenport
Sci. SAGE KE 2003 (15), nw56. [DOI: 10.1126/sageke.2003.15.nw56]
[Full text]

Spark of Life Mutation in worm insulin-like gene kindles longevity pathway (Insulin-related signaling).
9 April 2003
R. John Davenport
Sci. SAGE KE 2003 (14), nw55. [DOI: 10.1126/sageke.2003.14.nw55]
[Full text]

Senescence Tip-Off Tacky telomere ends erode as cells age (Telomeres; Cellular senescence).
26 March 2003
R. John Davenport
Sci. SAGE KE 2003 (12), nw49. [DOI: 10.1126/sageke.2003.12.nw49]
[Full text]

SAGA of Dying Neurons Disease-causing protein blocks histone modification (Neurodegeneration; Chromatin structure).
26 March 2003
R. John Davenport
Sci. SAGE KE 2003 (12), nw47. [DOI: 10.1126/sageke.2003.12.nw47]
[Full text]

Rescue Code DNA repair might depend on patterns of histone modifications (DNA repair; Chromatin structure).
19 March 2003
R. John Davenport
Sci. SAGE KE 2003 (11), nw45. [DOI: 10.1126/sageke.2003.11.nw45]
[Abstract] [Full text]

Death Be Not Degrading Parkinson's protein trashes cell-suicide protein to block neuron death (Parkinson's disease; Protein degradation; Apoptosis).
12 March 2003
R. John Davenport
Sci. SAGE KE 2003 (10), nw41. [DOI: 10.1126/sageke.2003.10.nw41]
[Abstract] [Full text]

Clearance Cell Astrocytes melt amyloid plaques (Alzheimer's disease; Neurodegeneration).
5 March 2003
R. John Davenport
Sci. SAGE KE 2003 (9), nw39. [DOI: 10.1126/sageke.2003.9.nw39]
[Abstract] [Full text]

Protective Parents Yeast moms bear brunt of protein damage (Oxidative damage; Replicative life span).
5 March 2003
R. John Davenport
Sci. SAGE KE 2003 (9), nw35. [DOI: 10.1126/sageke.2003.9.nw35]
[Abstract] [Full text]

Into Thick Air Polyamines help bacteria survive oxygen overload (Oxidative damage).
26 February 2003
R. John Davenport
Sci. SAGE KE 2003 (8), nw32. [DOI: 10.1126/sageke.2003.8.nw32]
[Abstract] [Full text]

Get Wild Do the genetic rules of aging in the lab apply in less civilized conditions?
26 February 2003
R. John Davenport
Sci. SAGE KE 2003 (8), ns2. [DOI: 10.1126/sageke.2003.8.ns2]
[Abstract] [Full text] [PDF]

When Tips Disappear, the End Is Near Short telomeres presage mortality, but do they cause it? (Telomeres).
5 February 2003
R. John Davenport
Sci. SAGE KE 2003 (5), nw24. [DOI: 10.1126/sageke.2003.5.nw24]
[Abstract] [Full text]

Lasting Without Fasting Zapping insulin signaling in fat helps well-fed mice persist (Insulin-related signaling; Diabetes).
5 February 2003
R. John Davenport
Sci. SAGE KE 2003 (5), nw21. [DOI: 10.1126/sageke.2003.5.nw21]
[Abstract] [Full text]

Joining Forces Elixir, Centagenetix unite (Therapeutics; Gero-Tech).
22 January 2003
R. John Davenport
Sci. SAGE KE 2003 (3), nw12. [DOI: 10.1126/sageke.2003.3.nw12]
[Full text]

Parc'n Brake Relative of Parkinson's protein impounds p53 in the cytoplasm (Cancer; Protein transport).
22 January 2003
R. John Davenport
Sci. SAGE KE 2003 (3), nw11. [DOI: 10.1126/sageke.2003.3.nw11]
[Full text]

No ALTernative For hard-core cancer cells, only telomerase will do (Telomeres; Cancer).
8 January 2003
R. John Davenport
Sci. SAGE KE 2003 (1), nw3. [DOI: 10.1126/sageke.2003.1.nw3]
[Abstract] [Full text]