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Vacuum in Vials
Follow this procedure to measure the volume of the air space at the top of the vial: Weigh a new vial, then fill the air space with water and re-weigh. The difference in weight (grams) = air volume (ml). Typical values are 11 ml for a 50 ml vial, and 7 ml for a 20 ml vial.
Surprisingly, you don't need to know the total volume of the vial or how much fluid it contains!
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